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Book Preface Medical Physiology We are delighted that the physiological community so eagerly welcomed the Second Edition of our book. The 3-fold philosophy that has guided us in the previous editions has endured as we prepared the Third Edition. First, we combine the expertise of several authors with the consistency of a single pen.

Oct 5, 2016 - Medical Physiology, 3e PDF Book, By Walter F. Boron MD PhD and Emile L. Boulpaep MD, ISBN:, Genres: Medical.

In the First Edition, we achieved this singleness of pen by sitting—shoulder to shoulder—at a computer as we rewrote the primary copy of our authors, line by line. By the time we began editing the Third Edition, one of us had moved from New Haven to Cleveland. Even so, we continued to edit jointly and in real time—monitor to monitor—using desktop-sharing software. After more than two decades, we have become so accustomed to each other’s writing styles that we can literally finish each other’s sentences.

Amiga workbench rom. Second, we still integrate physiological concepts from the level of DNA and epigenetics to the human body, and everything in between. Third, we complete the presentation of important physiological principles by pairing them with illustrations from pathophysiology, thereby putting physiology in a clinical context.

In this Third Edition, we have updated the entire book to reflect new molecular insights. In the process, we have shortened the printed version of the book by 40 pages. The Third Edition contains 20 new or redrawn figures as well as enhancements to 125 others. Similarly, we included over 190 tables. In the First Edition, we launched the concept of online-only Notes—electronic footnotes that were available on the Student Consult website.

These Notes (indicated by icons in the print version of the book) amplify concepts in the text, provide details and derivations of equations, add clinical illustrations, and include interesting facts (e.g., biographies of famous physiologists). With the increased use of online materials and eBooks, our readers may welcome our updating of the previous Notes as well as a 13% increase in the total number of Notes for the Third Edition, for a total of about 750. In the Second Edition, we provided the reader with numerous crosslinks to explanatory materials within the book by providing chapter numbers. In the Third Edition, we greatly expand the number of such crosslinks—but now refer the reader to specific pages in the print, and link the reader to specific paragraphs in the eBook.

The eBook provides references to scientific literature. In Section II (Physiology of Cells and Molecules), fresh insights led to substantial revisions in Chapter 4 (Regulation of Gene Expression), including the subchapter on epigenetics, and another on posttranslational modifications. Moreover, advances in physiological genomics and the understanding of genetic diseases led to major expansions of two tables—one on the SLC family of transporters (Table 5-4 in the chapter on Transport of Solutes and Water) and the other on ion channels (Table 6-2 in the chapter on Electrophysiology of the Cell Membrane).

In both tables, our updates help the reader navigate through what sometimes are multiple systems of terminology. In Section III (The Nervous System), new molecular developments led to major changes in Chapter 15 (Sensory Transduction), including the transduction of taste. In Section IV (The Cardiovascular System), we have improved the molecular underpinning of the ionic currents in Chapter 21 (Cardiac Electrophysiology and the Electrocardiogram). In Section VI (The Urinary System), we welcome Peter Aronson as a new co-author. Improved molecular insights led to major improvements in Chapter 36, including the subchapters on urea, urate, phosphate, and calcium. In Section VII (The Gastrointestinal System), Chapter 43 (Pancreatic and Salivary Glands) underwent significant modernization, including an expansion of the treatment of salivary glands.